Patients might also use simpler diaries or logs of sexual activity noting each attempt at intercourse, whether penetration was successful, and whether the erection was maintained to climax (these correspond to the Sexual Encounter Profile (SEP) questions often used in ED studies)
it should be discontinued if pregnancy occurs
Side effects of orlistat can be unpleasant: oily spotting, gas, stomach pain, fecal urgency or incontinence, soft stools, and the possibility of serious liver injury can occur
The loading-then-maintenance approach comes from TB-500 protocols you hit it hard initially to get cells migrating, then taper to a maintenance frequency
Direct head-to-head trials are not yet available, but comparing across studies suggests retatrutide produces approximately 6-10 percentage points more weight loss than tirzepatide at equivalent treatment durations
Mounjaro starts at a 2.5 mg weekly dose and increases every four weeks up to a maximum of 15 mg, a process that lasts for up to 21 weeks